Histology Detective and Brains Cape

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1 September 2015

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This case study focuses on the identification of metastatic tissues — cells that are “out of place” causing tumors elsewhere in the body. Name the cells you identified in this sample of lung tissue and the main characteristics that you can use to distinguish them.

From the observation of the sample there are variety of cells which can be identified as melanocytes. The main characteristics that can be used in distinguishing them is their attachment to the stratified squamous epithelial tissue. Moreover, they are larger and darker compared to the surrounding calls. Melanocytes are densely packed and have only one nucleus.

How did you use the main characteristics of different tissues that you learned in your lecture and lab sections as the basis for identifying those cells responsible for the tumor?

I applied my histology knowledge from my lectures in distinguishing the features of different cells. I had knowledge on how melanocytes and the natural cells look like on a slide hence it was very easy distinguishing and describing the cells. The cells under observations were abnormal from their look. They were larger in size, darker in color and round. Moreover. Their nucleus were larger compared to the other nucleus of the normal cells and has less cytoplasm. The melanocytes on the slide is always darker compared to the normal cells. According to Garbe et al (2010), there exists significant differences between the tumor cells and the native cells since the tumor cells are widespread in the extracellular fluid, are larger, much darker and more so cube shaped. On the other hand, the native cells are packed densely, smaller, and elongated.

In addition to the information in the case presentation (including the web sites contained in the case itself), what other information did you find to determine the identity of the cells and whether one type of cell had migrated from elsewhere in the body? Where did you find this information?

What does each of these additional items contribute to the solution of the case? For example, the item contains data from specific tests, trials, or experiments, or presents analyses that can be used to understand the main issues in this case.

The article “Diagnosis and treatment of melanoma: European consensus-based interdisciplinary guideline” provided experimental illustrating melanoma components. This affirmed that native cells can be differentiated from the invasive cells by features such as arrangement, form and color. The study used histology in identifying the invasive cells from the non-invasive ones (Garbe et al, 2010).

In the NIH article, “Diagnosis and treatment of early melanoma,” majorly the study was based on histology. The study distinguished fully developed melanoma and the early melanoma by categorizing their histological features. Moreover, they identified melanoma stages and different types of melanoma with application of histology (NIH et al, 1992).

In the third study, researcher physicians in two universities in three different melanoma cases of various origins in the body. However, all the characteristics of the abnormal cells were distinguished to be melanocytes. The identified abnormal features of the cells are similar to the ones in this case study, hence proving that the abnormal cells observed in the lung tissue were melanocytes (Sonda et al, 2008).

What other findings or information in this case are consistent with the information you located? Name those similarities in each of your additional resources. How do these resources apply what you have learned about identifying tissues and cells histologically?

From the article I reviewed, there was similarity with the case study in many areas. First, all the studies and the case used a similar method in diagnosing melanoma. They applied the cells histological characteristics in determining their status whether they are noninvasive or invasive cells. The characteristics identified helped in classification of the cells and in determining their origin.

What findings or information in each of the additional resources are not consistent with the findings in this case? Name those differences in each of your additional resources. How do these resources apply what you have learned about identifying tissues and cells histologically?

In the article “Diagnosis and treatment of early melanoma,” the study asserted that the cells making melanoma were the stratified melanoma epithelium (NIH et al, 1992). This contradicts the results of the case

If your proposed resolution of the case is correct, what other observations might we expect to find in this case?

Other observations we might find include metastasis of the tumor to other organs hence the patients could suffer from other compounded problems like neurological problems, digestion and bleeding.

Give your solution to this case and, on a scale of 1–5, rate how confident you are in your conclusions in questions 1 and 2

I would rate my confidence at 5 out of 5 because of the observable characteristics of melanoma

In considering your resolution and level of confidence level from question 8, describe how you located the information you used in this case.

To begin the search, I started with the most comprehensive data base that is Cumulative Index to Nursing and Allied Health (NINAH) (Kennedy 2009). The search then continued to search engines such as British Nursing Index, MEDLINE. Moreover PubMed and NCBI were other major search engines which assisted some of the relevant articles. These search engines were used because they contained most of the peer review articles and books. To limit and narrow down the search for articles, internal searches of the databases was used by inserting full length of texts and searching the relevant articles from the list of journals displayed. Moreover, I limited myself to the current articles of up to 5 years

What you might do differently if you had it to do over again? For example, would you use different resources and strategies? Different information?First, I would use different relevant articles to make companions of different studies. Moreover, I would try using group work to get opinions and arguments of different group member.


Garbe, C., Peris, K., Hauschild, A., Saiag, P., Middleton, M., Spatz, A., Grob, J. J., … Eggermont, A. (January 01, 2010). Diagnosis and treatment of melanoma: European consensus-based interdisciplinary guideline. European Journal of Cancer, 46, 2, 270-283. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/19959353Kennedy, J. R. (2009). Library research guide to education: illustrated search strategy and sources. Ann Arbor, Mich, Pierian Press.NIH Consensus Development Conference on Diagnosis and Treatment of Early Melanoma, & National Institutes of Health (U.S.). (1992). Diagnosis and treatment of early melanoma. Bethesda, Md: U.S. Dept. of Health and Human Services, National Institutes of Health, Public Health Service, Office of Medical Applications of Research. Retrieved from http://consensus.nih.gov/1992/1992Melanoma088html.htmSonda, Vemon K., MD, Zager, Jonathan S., MD, Messiana, Jane L., MD. Hemonc today. (2008, Oct 10). Retrieved from http://www.hemonctoday.com/article.aspx?rid=37772

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